Session 1

08:30 - 08:45
 

Welcome from the committee
 

08:45 - 09:40
 

Highlight Speaker: Mauno Vihinen, Tampere University (Finland)
Genetic variations: origin, effects and prediction.

09:40 - 10:05
 

Christian Schaefer, Technische Universitat Munchen (Germany)
Can we predict structural change upon point mutation?

10:05 - 10:30
 
 

Gilad Wainreb, Tel Aviv University (Israel)
Protein stability: A single recorded mutation aids in predicting the effects of other mutations in the same amino acid site.
 

10:30 - 10:45
 

Coffee Break
 

10:45 - 11:10
 

Piero Fariselli. University of Bologna (Italy)
Predicting cancer-associated germline variations in proteins.

11:10 - 11:35
 

Alain Laederach, University of North Carolina, Chapel Hill (USA)
Effects of disease-associated SNPs on the structure of the transcriptome.

11:35 - 12:10
 

Keynote Speaker: Burkhard Rost, Technische Universitat Munchen (Germany)
Trivial step from predicting the effects of SNPs to medicine.

12:10 - 12:25
 

Company Presentation: Frank Schacherer, BIOBASE GmbH.
Manually curated databases for SNP analysis.

12:25 - 13:30

Lunch Break and Poster Session with the Authors

Session 2

13:30 - 14:25
 

Highlight Speaker: Atul J. Butte, Stanford University (USA)
Clinical Assessment Incorporating a Personal Genome.

14:25 - 14:50
 

Konrad Karczewski, Stanford University (USA).
Assessing Functional and Clinical Significance of Regulatory Variants

14:50 - 15:15
 
 
 

Joel Dudley, Stanford University (USA).
Evolutionary meta-analysis reveals ancient constraints affecting missing heritability
and reproducibility in disease association studies.
 

15:15 - 15:30
 

Coffee Break
 

15:30 - 15:55
 

Adam Frankish, Wellcome Trust Sanger Institute, Hinxton (UK)
Is Understanding Alternative Splicing Important in Interpreting the Potential Functional Effects of SNPs?

15:55 - 16:20
 
 

Sudhir Kumar, Arizona State University, Tempe (USA).
Comparative Genomics as an Evolutionary Telescope for Genomic Medicine to Peer into the Universe of Human Mutations.

16:20 - 16:55
 
 

Keynote Speaker: Steven Brenner, University of California, Berkeley (USA).
CAGI Experiments
 

16:55 - 17:45
 
 

Round Table discussion
Christopher Baker, Maricel Kann and Sean Mooney
 

17:45 - 18:00

Closing remarks from the committee.